toxicological assessment of combined chemicals in the environment

Comprehensive resource covering toxicology fundamentals, distribution of pollutants in the environment, and research methodologies for toxicological assessment of chemical mixtures

Toxicological Assessment of Combined Chemicals in the Environment offers an in-depth exploration of various approaches and molecular mechanisms regarding how minor alterations in chemical mixtures can influence an organism’s toxicity, along with discussion of the challenges associated with assessing mixtures.

The first section of the book provides a concise introduction to the background and significance of combined toxicity. Section two delves into the primary sources and enrichment mechanisms of different chemical mixtures, elucidating the biological exposure pathways of these compounds. Section three introduces both classical and emerging toxicological research models in detail. Building on the descriptions of compound emission, migration, accumulation, and transformation processes, and the analysis of combined molecular toxicity in the preceding sections, section four introduces computer mathematical modeling methods for hazard assessment of compound mixtures. The final section details the challenges and future trends in this field.

Written by a highly qualified author and seasoned research contributor in the field, Toxicological Assessment of Combined Chemicals in the Environment covers sample topics including:

• The degradation, oxidation, absorption, distribution, biotransformation, and excretion of various compounds in both the environment and in organisms
• A variety of cell models and in vivo research models of model organisms, supplemented with case studies
• Combined molecular toxicity mechanisms of heavy metals, pesticides, persistent organic pollutants (POPs), and pharmaceutical and personal care products (PPCPs)
• Principal sources, fate, and mechanism of chemical mixtures in the environment, as well as experimental designs and sampling strategies for combined toxicity studies based on concentrations

Toxicological Assessment of Combined Chemicals in the Environment serves as a valuable reference for researchers, students, and policymakers involved in environmental management and protection. It is particularly relevant for toxicologists, risk assessors, and those engaged in the molecular modeling of toxic mixtures.

De-Sheng Pei, PhD, Professor & Doctoral Supervisor, School of Public Health, Chongqing Medical University. He is currently engaged in research on animal disease models, germ-free fish models, toxicological effects of environmental pollutants, and molecular mechanisms of disease caused by environmental pollutants. His discoveries have been published in more than 180 research papers.

Yiyun Liu, PhD, School of Public Health, Chongqing Medical University. In 2022, Dr. Liu graduated from the Research Center for Eco-Environmental Science (RCEES), Chinese Academy of Sciences.