3d/4d printing of bioadhesive pharmaceutical systems: additive manufacturing and perspectives

This book features a brief history of additive manufacturing and 3D/4D printing techniques, as well as the advantages, applications, and overall challenges facing the technology. It then focuses on the applications of bioadhesive systems for drug delivery.

3D/4D Printing of Bioadhesive Pharmaceutical Systems: Additive Manufacturing and Perspectives, explores recent discoveries of 3D printing in the development of pharmaceutical systems and drug delivery. Specifically, it discusses the main polymers/materials used in the development of bio-adhesive pharmaceutical systems and explains the importance of bio-adhesiveness of drug release through 3D printing. The authors also introduce the main strategies necessary to achieve a proper drug delivery system through 3D printing, and examine the adhesiveness of these systems on the skin as the mucosa decreases with the elimination of the drug by the body. Finally, the book brings all the necessary specifications to obtain a bioadhesive system with suitable bio-ink to obtain the best 3D/4D printing.

This book is written with the objective of helping students start their studies in pharmaceutical engineering, bioengineering and additive manufacturing. Moreover, engineering professionals can use the book to improve the performance of 3D/4D printers for this type of system.

Marcos Luciano Bruschi is an Associate Professor, Department of Pharmacy, State University of Maringa, Parana, Brazil. Dr. Marcos L. Bruschi joined the State University of Maringa (UEM) in 1998 as assistant professor of Pharmaceutics and became associate professor in 2014. He was awarded the degree of Doctor in Pharmaceutical Sciences from School of Pharmacy, University of Sao Paulo (USP), with a period as research fellow at Queen’s University of Belfast (QUB), Northern Ireland (UK). In 2014, he returned to QUB, Northern Ireland, to complete a period of post-Doctoral studies in School of Pharmacy. His current research focuses on the development of drug delivery systems using different strategies to modify and control the drug delivery, including nanotechnology and the development of advanced thermoresponsive bioadhesive platforms, micro/nanostructured particles, 3D printing, natural products and photodynamic therapy. He is the coordinator of the Laboratory of Research and Development of Drug Delivery Systems (LABSLiF) from State University of Maringa, Brazil.

Denise Tiemi Uchida is a PhD student in Pharmaceutical Sciences working on the development of bioadhesive drug delivery systems by 3D printing at the Laboratory of Research and Development of Drug Delivery Systems (LABSLiF) from State University of Maringa, Brazil.

Mariana Carla de Oliveira is a PhD student in Pharmaceutical Sciences working on the development of controlled drug delivery systems at the Laboratory of Research and Development of Drug Delivery Systems (LABSLiF) from State University of Maringa, Brazil.