The Design and Analysis of Sequential Clinical Trials

Sequential clinical trials are those where data from patients treated at the beginning of a trial can be analyzed while the trial is on-going and subsequent patients are recruited. This analysis provides stopping rules whereby the number of patients involved can be limited without affecting the results. This revised edition includes reference to PEST software (Planning and Education of Sequential Trials) and covers Bayesian Analysis of Sequential Trials.

John Whitehead is the author of The Design and Analysis of Sequential Clinical Trials, Revised, 2nd Edition, published by Wiley.