Skin cancer represents a global medical challenge, as its prevalence, morbidity, and mortality constitute a public health problem. This book presents the latest findings regarding the diagnosis, therapy and prognosis of Non-Melanoma Skin Cancer (NMSC), including Basal Cell Carcinoma, focusing on different therapeutic modalities. In addition, the most up-to-date findings regarding the epidemiology of SC are provided, and an innovative technique for the early diagnosis of melanoma is also presented.