Synaptic Plasticity in Neurodegenerative Disorders

This book explores the pivotal role of synaptic plasticity in the pathogenesis, progression, and potential treatment of neurodegenerative disorders. The initial chapter provides an in-depth understanding of the complexity and impact of neurodegenerative conditions. It discusses the association of mitochondrial dysfunction, epigenetic influences, and neuroinflammation with synaptic plasticity in neurodegenerative diseases. The following chapters review the dynamic changes that occur at the cellular and synaptic levels in Parkinson’s disease, Alzheimer’s disease, and Huntington’s disease, paving the way for innovative therapeutic strategies. Furthermore, the book presents various computational tools and methodologies essential for enhancing our understanding of synaptic plasticity. It examines the transformative role of artificial intelligence tools in addressing synaptic impairment across various neurodegenerative diseases.

• Discusses the role of synaptic plasticity in neurodegenerative diseases, shedding light on how dynamic changes occur at the cellular and synaptic levels
• Explores the transformative role of artificial intelligence tools in addressing synaptic impairment across various neurodegenerative diseases
• Provides a comprehensive overview of neurodegenerative disorders, including pathogenesis, etiology, and treatment strategies
• Presents tools and techniques used to simulate the complex system biology of synaptic plasticity
• Examines the role of computational neuroscience in understanding and potentially treating conditions such as multiple sclerosis and amyotrophic lateral sclerosis

Toward the end, the book explores the role of synaptic impairment and computational neuroscience in understanding and potentially treating conditions such as multiple sclerosis and amyotrophic lateral sclerosis. With its multifaceted approach, this book serves as a useful resource for researchers, clinicians, and students in the fields of neuroscience, computational biology, and neurology.

Dr. Sangeeta Singh is an Assistant Professor in the Department of Applied Science at the Indian Institute of Informational Technology, Allahabad (IIIT A), Prayagraj, Uttar Pradesh (UP), India. Prior to joining IIIT Allahabad, she worked at the ICAR Indian Veterinary Research Institute in Izzatnagar, Bareilly (UP), India. She completed her Ph.D. in 2010. Dr. Singh’s research interests include neurodegenerative disorders and regenerative medicine to promote neuronal repair and regeneration. She has received various research grants from the Science and Engineering Research Board (SERB) and the Department of Science and Technology, India. Dr. Singh has published more than 50 research articles in high-impact journals, in addition to contributing book chapters and conference proceedings. Furthermore, Dr. Singh serves as a reviewer for various reputable journals and is also a Life Member of various esteemed societies, such as the Indian Academy of Neurosciences (India), the Association of Microbiologists of India, and the Society for Biomaterials and Artificial Organs India.

Dr. Santosh Kumar Singh is a Senior Scientist at the Centre of Experimental Medicine and Surgery (CEMS), Faculty of Medicine, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India. He earned his Ph.D. from the Botany Department (Institute of Science), BHU, in 1998. In 2003, he served as a Visiting Scientist at the Department of Photosynthesis, Institute of Physical Biology, University of South Bohemia, Czech Republic. Dr. Singh has published more than 75 research articles in high-impact and reputable journals. His research primarily focuses on Drug Discovery and Development, Microbial Biotechnology, and Nanobiotechnology. Dr. Singh is a member of the Mycological Society of India, the Society of Biological Chemists, India, and the Society for Ethnopharmacology, Kolkata, India (SFE INDIA). He has served as a resource person in the Karyashala Training Course under the Accelerate Vigyan Scheme, SERB, and DST. Notably, he was awarded the ＂National Award for Outstanding Efforts in Science and Technology Communication through Innovative and Traditional Methods (2021)＂ by the Department of Science and Technology, Ministry of Science and Technology, Government of India. In 2020-2021, he also received the Order of Academic Excellence in Publication from the Institute of Medical Sciences, Banaras Hindu University, Varanasi.

Dr. Sachchida Nand Rai is a Research Associate (ICMR RA) at the Centre of Experimental Medicine and Surgery, Institute of Medical Sciences, Banaras Hindu University (BHU), Varanasi. Dr. Rai completed his Ph.D. from the Biochemistry Department (Institute of Science), BHU. Before joining BHU as a Research Associate, he held a post-doctoral fellowship at the Centre of Biotechnology, University of Allahabad, Prayagraj, India. Additionally, he serves as an editorial board member for many renowned journals and has published several research articles in journals of high repute.