Molecular Targets and Therapeutic Interventions Against Neurodegenerative Diseases

This book comprehensively explores the latest advancements in the understanding, diagnosis, and treatment of neurodegenerative diseases. The chapters provide an in-depth review of current approaches and treatment strategies for Alzheimer’s disease, offering insights into the latest developments and breakthroughs. It also reviews the cutting-edge research on potential novel targets for Alzheimer’s pharmacotherapy, with a focus on JNK3, GSK3β, and Fyn kinase inhibitors, providing an update on related approaches and their implications. It discusses the potential of ethnomedicines as a promising tool for mitigating Alzheimer’s disease, offering insights into traditional remedies and their modern applications. Additional chapters explore the influence of microglia, the neuropharmacological mechanisms associated with SARS-CoV-2, and the molecular intricacies of Parkinson’s disease. The book further covers the evolving role of artificial intelligence and machine learning in the management of neurodegenerative disorders. The chapters also examine the role of nanotechnology in addressing the challenges of diseases like multiple sclerosis. Towards the end, the book examines the role of oxidative damage in neurodegeneration and its management in related disorders. This book is an important source for neuroscientists, neurologists, and students of neuroscience.

Dr. Vaishali Manikaro Patil presently holds the position of Professor (Associate) and Head at Charak School of Pharmacy, Chaudhary Charan Singh University in Meerut, India, and also serves as a Visiting Professor at the Faculty of Pharmaceutical Sciences, UCSI University in Kuala Lumpur, Malaysia. With over 16 years of academic and 3 years of industrial experience, her primary research lies in Medicinal Chemistry and Computer-Aided Drug Design, focusing on quantitative structure-activity relationship studies, drug-receptor interactions, and the synthesis of small heterocyclic molecules. Dr. Patil, a recipient of prestigious awards, has authored numerous research papers, books, and book chapters, contributing globally through lectures and participation in scientific communities like the American Chemical Society and APTI-India.

Dr. Dileep Kumar, holding degrees from Manipal University and S.G.S.I.T.S Indore, served as an Assistant Professor at Poona College of Pharmacy and currently holds a visiting faculty position at the University of California, Davis. With research interests in the design of GluN2B selective NMDA receptors antagonists and Amyloid-β protein aggregation inhibitors for Alzheimer’s disease treatment, Dr. Kumar actively contributes to cancer research at UC Davis Comprehensive Cancer Center.

Dr. Neeraj Masand, an Assistant Professor at Lala Lajpat Rai Memorial Medical College in Meerut, holds degrees from North Maharashtra University and Dr. A. P. J. Abdul Kalam Technical University, Lucknow. With over 16 years of academic and research experience, his current research focuses on designing gamma-secretase inhibitors for Alzheimer’s disease treatment and synthesizing novel heterocyclic analogues.