P53 in Breast Cancer: Molecular Mechanisms, Clinical Implications, and Therapeutic Targets

p53 in Breast Cancer: Molecular Mechanisms, Clinical Implications, and Therapeutic Targets comprehensively reviews the role of p53 in breast cancer development, progression, and treatment. It explores the multifaceted functions of p53, from its fundamental connection to breast cancer and pathway mechanisms to its influence on cancer metabolism and the impact of mutational alterations. The initial chapters discuss the complex landscape of p53’s involvement in cancer metabolism, the ramifications of its mutations, and its crucial role as a tumor suppressor. The subsequent chapters review the regulatory functions of p53 in cell death, DNA repair, genomic stability, and cell cycle dynamics, highlighting its interactions with transcription factors, DNA repair enzymes, and family members p63 and p73. It further reviews the regulation of mutant p53 via post-translational modifications and delves into the approaches to combat mutated p53, highlighting targeted therapies and efforts to overcome chemoresistance. The chapters also address the role of p53 biomarkers in diagnosis and prognosis, the optimization of treatment responses, and the impact of nutrition on p53 activity. This book is an important resource for oncology and molecular biology researchers.

Key Features

• Provides a thorough examination of the p53 gene and its crucial involvement in breast cancer.
• Explores the critical implications of mutational alterations in p53 on the development and progression of breast cancer.
• Examines the role of p53 in managing apoptosis and contributing to DNA repair and genomic stability.
• Discusses the complex interactions of p53 with transcription factors, DNA repair enzymes, p63, and p73.
• Highlights the role of p53 as a biomarker in diagnosing and predicting breast cancer prognosis.

Dr. Manzoor Ahmad Mir is presently working as a scientist and head of department at the Department of Bioresources, University of Kashmir. He holds master’s degree in Zoology with Gold Medal from HNBG Central University and got his Ph.D. from Jawaharlal Nehru University New Delhi and CSIR-Institute of Microbial Technology, Chandigarh, in the field of Immunopathology. His research interest is cancer biology with specialization in drug repurposing and combination therapy of breast cancer and to elucidate the molecular mechanism behind it, besides use of natural agents in treating cancer. He is also working on expression pattern and prognostic significance of chemokines/cytokines of CDKs in breast cancer, as well as the virtual screening of drugs for cancer treatment and their mechanistic elucidation. He has published more than 50 high-impact research papers and book chapters, in recognition of which he has received several awards. Dr. Manzoor has authored more than 16 books with international publishers. He is on the editorial board and reviewer of some prestigious journals and has been an invited speaker at various scientific meetings/conferences within India and abroad. He is member of many scientific organizations and societies, like American Association of Cancer Research, the Royal British Society, American Association of Clinical Oncology, International Immunology Association, etc. Dr Manzoor was awarded Teachers Associate Research Excellence Fellowship (TARE) by DST Govt of India and Summer Research Fellowship Programme (SRFP-2019) by Indian Academy of Sciences and National Science Academy. Dr Manzoor has developed Massive Open Online Course (MOOCs) in immunology, human genetics, and endocrinology for UG students sanctioned by UGC-Consortium for Educational Communication (CEC) SWAYAM Ministry of HRD Govt of India. He has research and teaching experience of 15 years in cancer biology, animal cell and tissue technology, molecular modelling and drug design, comparative immunology.