High levels of homocysteine, a sulfur-containing amino acid derived from methionine, have recently been identified as a very important risk factor in cardiovascular disease. Homocysteine abnormalities are also thought to contribute to birth defects and dementia. There are many common genetic disorders and problems (such as vitamin deficiency) that adversely affect the metabolism of homocysteine. In this book a team of the world's experts in the field provide a clear, current, clinical analysis of the biochemistry, genetics, and epidemiology of homocysteine disorders, providing a uniquely comprehensive account of the broad range of medical, nutritional and methodological implications of homocysteine for health and disease.