This engaging, hands-on science lesson introduces upper elementary students to the structure and function of the heart, blood vessels, and blood components, and explores how oxygen and nutrients are transported throughout the body. Designed for students in grades 4-6, the lesson features six interactive activities that help children investigate real-world biology through observations, models, experiments, and role play. What sets this lesson apart is the inclusion of a Google Slides presentation with embedded presenter notes. These notes provide step-by-step teaching cues, key talking points, and guided discussion prompts, allowing educators to lead the lesson with ease - even if they are not science specialists. This visual teaching aid integrates seamlessly with the student activities and is a key strength of the curriculum. Downloadable materials include: Printable materials and/or worksheets Supply list Google Slides presentation with instructor notes Instructions for accessing all digital materials are provided inside the book. Developed by the Gene-ius Day Program at the University of Hawai’i at Mānoa, this curriculum is part of the Science in Action: Hands-On Learning for Curious Minds series - designed to spark curiosity and bring science to life for young learners.