e-ASTROGAM (enhanced ASTROGAM) is a breakthrough Observatory space mission dedicated to the study of the Universe using gamma-rays in the mostly unexplored and crucial MeV-GeV energy range. e-ASTROGAM has been proposed for the ESA M5 mission. Thanks to its performance in the MeV-GeV domain, substantially improving its predecessors, e-ASTROGAM will open a new window on the non-thermal Universe, making pioneering observations of the most powerful Galactic and extragalactic sources. e-ASTROGAM will also determine the origin of key isotopes fundamental for the understanding of supernova explosion and the chemical evolution of our Galaxy. e-ASTROGAM has already collected the interest of more that 350 scientists from 19 different countries. About 100 scientists met in Padua from February 28 to March 2, 2017, to discuss some of the more relevant scientific aspects of the mission. This book collects their contributions.