Quantitative Susceptibility Mapping

Quantitative Susceptibility Mapping gives a systematic account of the fundamentals of physical concepts, technical algorithms, and biomedical applications associated with magnetic resonance imaging of tissue magnetism. Recent progresses in MRI phase analyses and in numerical optimization solvers of inverse problems and promising applications in studying iron and oxygen metabolisms and hemorrhage have attracted many people to investigate quantitative susceptibility mapping (QSM). The objective of this book is to provide a comprehensive and timely introduction for the newly formed and rapidly growing QSM community. Emphasis has been placed on clarity throughout the narrative. Detailed considerations are presented to clarify the subtleties of the physics of magnetism and magnetic resonance signals: - Thorough demonstrations of the forward problem from magnetic susceptibility to field. - Comprehensive descriptions of major approaches to solving the field to susceptibility inverse problem. - Specific examples of clinical and scientific applications. Engineers, physicists, and clinicians at all levels, from students to established investigators, will find Quantitative Susceptibility Mapping a useful aid in understanding the physical principles of magnetic resonance imaging of tissue magnetic properties.

ABOUT THE AUTHOR Professor Yi Wang is the Faculty Distinguished Professor of Radiology, Professor of Biomedical Engineering, and co-Director of the MRI facility at Cornell University. Professor Wang is a Fellow of the American Institute for Medical and Biological Engineering and the International Society of Magnetic Resonance in Medicine. Professor Wang has been serving as a scientific reviewer of grant applications for many agencies, including the National Institutes of Health (NIH), European Research Council, Research Grants Council of Hong Kong, Swiss National Science Foundation, and the Wellcome Trust of the United Kingdom. As a Principal Investigator, Professor Wang has been awarded many NIH grants for MRI-related research and education and has published more than 120 peer-reviewed journal papers. Professor Wang’s research interest has been in developing MRI technology for clinical applications using methodologies and tools from physics, mathematics, electronic engineering, computer science, and biology. Professor Wang has developed the real time navigator method to measure motion and modify data acquisition accordingly to compensate for motion artifacts in cardiac imaging, which has become widely adopted in research and clinical practice for cardiac and abdominal imaging. Professor Wang has pioneered the time resolved acquisition method for imaging contrast agent bolus in the routinely used contrast enhanced magnetic resonance angiography. Professor Wang has invented the multiple station stepping table technology using local coils for high throughput of imaging various body parts while the patient is transported through the magnet, which has become adapted in modern MRI systems and is required for the bolus chase peripheral magnetic resonance angiography. Recently, Professor Wang’s group has introduced the quantitative susceptibility mapping (QSM) technology by inverting the local magnetic field estimated from MRI signal. QSM is promising for investigating tissue magnetic biomarkers, including deoxyhemoglobin, ferritin, hemosiderin, calcification and contrast agents, and has potential applications for various diseases involving iron metabolism, oxygen metabolism and blood degradation. Professor Wang is currently working on research projects related to QSM, Bayesian approaches to MRI and applications in the brain, heart, and liver.