Rowland and Tozer’s Clinical Pharmacokinetics and Pharmacodynamics: Concept and Applications

Section 1  Basic Considerations
Chapter 1  Therapeutic Relevance
Chapter 2  Fundamental Concepts and Terminology

Section 2  Exposure and Response after a Single Dose
Chapter 3  Kinetics Following an Intravenous Bolus Dose
Chapter 4  Membranes and Distribution
Chapter 5  Elimination
Chapter 6  Kinetics Following an Extravascular Dose
Chapter 7  Absorption
Chapter 8  Response

Section 3  Therapeutic Regimens
Chapter 9  Therapeutic Window
Chapter 10  Constant-Rate Input
Chapter 11  Multiple-Dosage Regimens

Section 4  Individualization
Chapter 12  Variability
Chapter 13  Genetics
Chapter 14  Age, Weight, and Gender
Chapter 15  Disease
Chapter 16  Nonlinearities
Chapter 17  Drug Interactions
Chapter 18  Initiating and Managing Therapy

Section 5  Supplement Topics
Chapter 19  Distribution Kinetics
Chapter 20  Metabolites and Drug Response
Chapter 21  Protein Drugs
Chapter 22  Prediction and Refinement of Human Kinetics from In Vitro, Preclinical, and Early Clinical Data

Appendices
Appendix A
Appendix B
Appendix C
Appendix D
Appendix E
Appendix F
Appendix G
Appendix H
Appendix I
Appendix J
Appendix K
Index

 

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　　Over the last 35 years and four published editions, Clinical Pharmacokinetics and Pharmacodynamics: Concept and Applications, by Malcolm Rowland and Thomas N. Tozer, became the classic introduction to the fields of drug development and drug therapy optimization. This didactic masterpiece taught concepts of dose optimization in an exciting and stimulating way and encouraged further study of the field. It conveyed the joy that comes from mastering quantitative integration tools that can apply information from a wide variety of drug studies to make individual recommendations on choosing the best dosing regimen for individual patients.

　　It was a great honor and pleasure for us when the original authors asked us to take over the authorship for this and future editions. We are humbled to stand on the shoulders of these giants and we greatly appreciate their confidence in us. We have endeavored to keep the clear didactic structure of the previous editions while adding new developments in the field that is now called Pharmacometrics. One of the most significant changes during the years since the first edition of this book is the dramatic progress in computational technology that now allows sophisticated mathematical analysis of relatively complex scenarios. However, the goal has not changed: How can we best decide which dose, which dosing regimen, and which dosage form should be used for a patient which will have the highest probability of therapeutic success without dosing harm? This fifth edition was guided at each stag by this goal.