The self-controlled case series (SCCS) method is an epidemiological technique, similar to cohort and case-control studies, where cases are used as their own controls. It is flexible, easy-to-use, and can lead to substantial cost-saving in comparison to other methods. The method has grown in popularity in the epidemiology literature in the last twenty years, and has a wide range of applications. This book presents an overview of the methodology, illustrated through many examples and case studies. R software is used for all analyses, with code and data available on a supplementary website.