This compendium of clinical practice guidelines and policy statements from the American Academy of Pediatrics helps equip clinicians to provide equitable and inclusive care to vulnerable and underserved pediatric populations. It offers guidance on the care of such populations as immigrant children and their families; children and families who are black, indigenous or people of color; LGBTQ+ youth and their families; and more. Additionally, the compendium covers topics such as substance use disorders, trauma informed care, and care of youth involved in the legal system. Pediatricians, family medicine physicians, physician assistants, and nurse practitioners who care for children will find this collection useful.