A Framework for Global Natural Disasters Response introduces cases and frameworks that address global humanitarian logistics and disaster response conducted by the United States Navy (USN). The purpose of introducing these cases and frameworks is to identify those capabilities that enable efficient and effective responses to a humanitarian crisis or disaster. First, the monograph provides a motivation for the attention given to humanitarian assistance and disaster response by addressing climate change and the impact of natural disasters in the Asia Pacific region, which is the most heavily populated region on earth. Second, the authors identify metrics for determining operational readiness to respond to a disaster event. Third, the authors identify capabilities and competencies that have proven most effective among all those available to the United States Navy during a disaster response and draw upon several cases to illustrate the points empirically. Finally, the authors introduce a design perspective for considering the future of disaster response and focus on four design elements for building an effective disaster response: technology, organization, information, and policy.