Blockchain is a recent technology that is promising to revolutionize the way supply chains are designed and operated. Regarding its role in securing exchanges of data, this technology has remarkably changed the manner of governing the structure of the supply chain relationships and the way that transactions are made. Blockchain technology is likely to influence future supply chain practices by performing electronic integration, supporting partners’ connections, and offering real-time information flows. Thus, blockchain technologies are gaining interest among both academicians and professionals. This interest concerns the conceptual level and also the practical and concrete levels of the implementation of blockchain technology in supply chains. The Handbook of Research on Blockchain Technology and the Digitalization of the Supply Chain presents blockchain’s basic concepts and pertinent methods that contributed to meeting key supply chain management objectives. It determines the current trends and challenges in the use of blockchain to enhance supply chain management. Covering topics such as communication systems, documentation systems, and supply chain evolution, this major reference work is an excellent resource for business leaders and managers, logistics professionals, IT managers, students and educators of higher education, librarians, researchers, and academicians.