Designing Effective Supply Chains in Strategic Alignment with Demand Characteristics and Market Requirementsexamines supply chain management from a strategic point of view. It aims to provide a holistic exploration of existing supply chain strategies with most of its emphasis on product-driven strategies, and Fisher’s framework in particular. The authors explore the literature regarding the framework to present a picture of how it has been considered by researchers, and how it can best develop/improve. Due to the strategic role of inventories in supply chain management, the authors also analyze the framework from a mathematical view to investigate the extent to which it conforms to two existing inventory models, namely, the newsvendor model and the continuous review model, and to see how different product characteristics affect supply chain decisions. Furthermore, other product-driven supply chain strategies, such as leanness, agility, leagility, mass customization, and postponement, are reviewed.