Metastatic Bone Disease: An Integrated Approach to Patient Care

Skeletally related events make up approximately 20% of the cancer care economy. Advances in understanding the pathobiology and better biotargeted therapy and improved surgical technology are occurring continuously. Hundreds of thousands of patients are living longer with ever-increasing tumor burden, but patients can remain siloed in their care as they navigate across subspecialty treatments. This comprehensive text ties it all together around the patient, integrating all aspects of care.
Providing an integrated approach to the diagnosis and management of patients with metastatic bone disease (MBD), this revised and expanded text combines discussion of the pathobiology of the disease with the latest oncological and orthopedic treatment modalities. After opening with an examination of the epidemiology and impact of MBD, the biology of bone metastases are discussed, along with considerations of the tissue of origin, evaluation, biopsy andmedical therapy, including metabolic agents and biotargeting. The heart of the book presents oncological approaches (supportive, radiation and interventional) and principles of orthopedic surgical oncology, with subsequent chapters covering specific anatomy, from the pelvis to the lower extremity and the spine. Chapters on emerging surgical technology and future directions conclude the text. New to this edition are considerations around patient-reported outcomes.
Utilizing the latest clinical evidence and treatment techniques, Metastatic Bone Disease, Second Edition is standalone resource reflecting a comprehensive, patient-centric resource for all types of providers.

R. Lor Randall, MD, FACS, FAOA, Department of Orthopaedic Surgery, University of California Davis, Sacramento, CA, USA

The David Linn Chair in Orthopedic Surgery; Director, Sarcoma Advanced Research & Clinical Fellowships; Sarcoma Services, MSK Section; Chair, UCD Medical Group Planning Committee; Chair, UC Davis NCI-Designated Comprehensive Cancer Center Internal Advisory Committee; Medical Director, Shriners Hospital-UC Davis B.U.M.P.S. Clinic

Immediate Past President, Association of Bone & Joint Surgeons; Past President, Musculoskeletal Tumor Society; Past President, Connective Tissue Oncology Society; Chair Emeritus, Local Control, Children’s Oncology Group