Overcoming Breast Cancer Therapy Resistance: From Mechanisms to Precision and Ai-Powered Approaches

This book addresses the pressing problem of drug resistance in the treatment of breast cancer. It provides a comprehensive understanding of the complex mechanisms underlying drug resistance and presents the latest advances in therapeutic approaches to overcome this enormous challenge.

The book begins with an introduction to the biology of breast cancer, treatment modalities and the mechanisms of drug resistance. This includes the principles of drug resistance in targeted, immune-, endocrine and chemotherapy. In the following sections, the authors present innovative strategies to overcome drug resistance and new research directions, among others the role of the microbiome in drug resistance, molecular profiling of patients for personalized medical care, and new drug delivery systems. Finally, the book concludes with a discussion of the differences in the prevalence and treatment success of breast cancer between high- and low-income countries.

This book is an informative resource for students, researchers, and clinicians in the field of breast cancer research and oncology in general.

Zodwa Dlamini is a Professor of Molecular Oncology and known for her unwavering commitment to advancing precision oncology. At the core of her career is her pivotal role as the Founding Director of the Pan African Cancer Research Institute (PACRI). Additionally, as the Director of the SAMRC Precision Oncology Research Unit (PORU) and a DSI/NRF SARChI Chair in Precision Oncology and Cancer Prevention (POCP), she is fully committed to advancing precision medicine in the battle against cancer. Beyond her institutional leadership, Professor Dlamini also serves as a distinguished member of the American Association for Cancer Research (AACR) Regional Advisory Committee on Sub-Saharan Africa. She additionally guides the AACR Pathology Resources in Africa Advisory Group, actively identifying strategies to address gaps in cancer pathology services across the African continent. Professor Dlamini extends her contributions to the African Organisation for Research and Training in Cancer (AORTIC), where she actively influences the organization’s strategic direction and mission as a member of the Research Committee Scientific Advisory Board. Her dedication to advancing cancer research in Africa was honoured with a Special Award from the Council and Executive of the African Society of Morphology and was then admitted as an ＂Honorary Fellow＂ of the West African College of Morphologists. Moreover, she is an Overseas Fellow of the Royal Society of Medicine (London), Professional Member of the New York Academy of Sciences (USA) and a member of the Academy of Science of South Africa, highlighting her contributions to the field of Science. Through her multifaceted efforts, Professor Zodwa Dlamini remains steadfast in her commitment to shaping the ever-evolving landscape of cancer research and her journey is driven by an unshakable belief that cancer can be conquered, paving the way for a healthier and more equitable world.