This Open Access volume assembles experts from the United States and India to examine six issues essential to the safety and security of nuclear facilities, technologies, and materials: insider threats, organizational culture, emergency response, physical protection, control of radioactive sources, and cyber security. Each chapter includes papers by an Indian expert and by an American counterpart. This unique structure contrasts the countries’ diverse perspectives on nuclear security, situates technical problems within larger socio-political contexts, and identifies cooperative opportunities for the U.S. and India.