Trends in Biosensing Research: Advances, Challenges and Applications

This book reviews the latest developments and applications in the field of biosensing, providing readers with an update of the earlier, successful edition, Biosensing for the 21st Century. In this book, readers will find comprehensive key information on the advances and challenges in biorecognition elements and transduction principles, including examples of new materials and new methods. Ranging from engineering chimeric enzymes to the progress in electrochemical sensing of drugs, the book discusses the latest innovations in the field and thus, provides the reader with a profound overview. In the field of biological recognition the focus will be on switchable sensors by engineering new proteins, the development of Molecular Imprinted Polymers (MIPs) for proteins or even larger biological entities, the construction of complex nucleic acid - protein structures for affinity sensing and the application of whole microbes.

The book covers new trends in signal transduction which includes graphene-based field effect transistors, nanopores designed for high selectivity and sensitivity in analysis, plasmonic and nanophotonic sensing applying metal nanostructures up to new developments in microarray construction. An introduction in to the challenges in skin-interfaced systems for continuous biochemical sensing, offers a glimpse into the future of wearable technologies. Furthermore, actual areas of application of new sensing strategies such as the detection of various types of viruses and bacteria or the analysis of drugs will be highlighted.

Each chapter provides a scholarly yet accessible perspective on the latest trends in biosensor technology. Given its breadth, the book has an interdisciplinary appeal and engages a wide readership, from students and researchers to practitioners in academia and industry, interested in the fields of biochemical/biomedical engineering and in biosensing methodologies and applications.

Fred Lisdat is a Professor of Biosystems Technology at the Technical University of Applied Sciences Wildau, Germany. He is also the director of the Institute of Life Sciences and Biomedical Technologies (since 2014) and the study course director (since 2019). He plays an active role in international scientific organisations such as the International Society of Electrochemistry - ISE - (Chair of Bioelectrochemistry Division 2015-2019) or the Bioelectrochemical Society - BES - (Secretary general, President) and has organised several scientific meetings. His research interests include biosensors, recycling schemes, detection of reactive oxygen species, protein electrochemistry, label-free detection of DNA and proteins, artificial protein arrangements on electrodes, protein engineering, semiconductor nanostructures on electrodes for sensing, biofuel cells, carbon nanostructures, conducting polymers, macroporous electrodes and photobioelectrochemistry. He has authored 175+ peer-reviewed articles, 15 book chapters and 3 patents.

Nicolas Plumeré is a Professor of Electrobiotechnology at the TU Munich, Germany, with an active role in the council of the Bioelectrochemical Society, on the board of ECHEMS, and on the advisory board of Chemical Science (RSC). He organized 10+ scientific meetings and edited several special issues on the topic of bioelectrochemistry. His research group specializes in interfacing biocatalytic systems on electrodes for applications in energy conversion, electrosynthesis and electrochemical biosensing. Notable achievements include the integration of hydrogenase and CO2 reducing enzymes on electrodes to produce H2 and complex organic molecules using renewable energy. Fundamental findings on wiring enzymes with electrodes also led to applications in bioelectrochemical sensing for personalized medicine and precision agriculture.