Transcription Factors in Blood Cell Development

This book describes transcription factors in the context of hematopoietic development and reveal mechanistic insights how they orchestrate specific gene expression patterns. Several examples from lymphoid and myeloid lineages are given as well as particular examples of leukemia fusion proteins that contain a part of a transcription factor. In the given chapters covering each one particular example, the function of transcription factors is characterized in normal as well as leukemic contexts.

New technologies such as ChIP-Seq or RNA-Seq, that make use of genome-wide sequencing, have shown that such master regulators of blood cell development often work in combinatorial fashion and, when dysregulated, results in leukemogenesis.

This book is not only intended for experts but it should also be a useful resource for younger scientists or scientists from other disciplines, who may use this book as a stimulating starting point for further discoveries and/ or translational endeavors.

Dr. Tilman Borggrefe studied biochemistry at the Imperial College London before obtaining his PhD at the Basel Institute for Immunology (Switzerland). He performed postdoctoral studies at Stanford University (R. Kornberg laboratory, USA) and was Max-Planck independent group leader in Freiburg im Breisgau (Germany). Since 2012 he is professor for biochemistry at the University of Giessen (Germany).

Dr. Benedetto Daniele Giaimo studied biology at the University of Palermo (Italy) before obtaining his Ph.D at the Max Planck Institute of Freiburg im Breisgau (Germany). Since 2012, Dr. Giaimo is a scientist at the University of Giessen (Germany).