Almost all fields of dentistry are closely related to newly developed materials, and all clinical improvements often follow or go hand in hand with the creation and development of innovative and higher-performing materials, instruments, and equipment. Thanks to the application of contemporary dental materials, the effectiveness of clinical dentistry has witnessed remarkable advances. In recent years, thanks to digital technology and the frenetic development of the dental industry, new materials have been developed and proposed in each field of dentistry: prosthesis, restorative dentistry, endodontics, implantology, and orthodontics. Unfortunately, as often occurs, this productive challenge is not always accompanied by valid scientific research; consequently, the clinician finds at their disposal materials that are not necessarily better than the previous ones. Further studies are needed to gain relevant evidence for all recently introduced dental materials. This Special Issue contains high-quality research articles, clinical studies, review articles, and case reports focused on the latest advances and prospects of dental materials concerning all fields of dentistry.