Carbohydrate Chemistry in the Total Synthesis of Naturally Occurring Glycosides

Carbohydrate Chemistry in the Total Synthesis of Naturally Occurring Glycosides

Revolutionize your manufacturing processes and more with this groundbreaking introduction

Carbohydrates and complex glycosides are important classes of molecules. The ubiquitous glycosides are extremely diverse in structure and functions, and many of them are of pharmacological significance. Purification of a homogeneous glycoside from the nature sources, especially in an appreciable amount, is always difficult. Chemical synthesis provides a feasible access to the homogenous glycosides and their congeners.

Carbohydrate Chemistry in the Total Synthesis of Naturally Occurring Glycosides presents about 10 families of naturally occurring glycoside natural products, including about 150 molecules that organic chemists have devoted a lot of effort toward their synthesis. In each example, the background of each natural glycoside, including its natural resources, its isolation process and its bioactivities have been described; the total synthesis of the natural glycoside is presented with special emphasis on the glycosylation reaction, the strategy on saccharides assembly, the protecting group manipulation, and the method for the synthesis of the rare saccharide units. Readers can clearly see the progress of total synthesis of naturally occurring glycosides, from early to current arts, from simple to complex molecules, and from tedious strategy to highly efficient and economical methodologies in this book. It will highly benefit the further developments in the total synthesis of naturally occurring glycosides and synthetic carbohydrate chemistry.

Carbohydrate Chemistry in the Total Synthesis of Naturally Occurring Glycosides is ideal for Organic Chemists, Biochemists, Pharmaceutical and Medicinal Chemists, Natural Products Chemists, and Pharmaceutical Industry

Biao Yu is a professor and currently a deputy director of the Shanghai Institute of Organic Chemistry (SIOC) and the director of State Key Laboratory of Bioorganic and Natural Products Chemistry. Professor Yu obtained his Bachelor’s degree from Peking University in 1989 and his Doctoral degree from SIOC in 1995. He has spent 20 years working on carbohydrate chemistry, especially the total synthesis of naturally occurring glycosides. Professor Yu has published over 250 scientific papers and been given a lot of awards, such as National Natural Science Award and Fellow of the Royal Society of Chemistry.

Xiaoyu Yang is an assistant professor at the School of Physical Science and Technology, ShanghaiTech University. Professor Yang obtained his Bachelor degree from Nanjing University in 2003 and his Doctoral degree from SIOC in 2012, under the supervision of Professor Yu. Professor Yang’s doctoral thesis was focused on the total synthesis of naturally occurring glycoconjugates; he and his co-workers finished the first total synthesis of landomycin A and Jadomycins. Professor Yang also won some awards, such as being selected as Finalists of Reaxys PhD Prize and Eli Lily Aisa Outstanding Graduate Thesis Award (first class).