Biomaterials Effect on the Bone Microenvironment: Fabrication, Regeneration, and Clinical Applications

Biomaterials Effect on the Bone Microenvironment

Practical resource on clinical bone regeneration from a variety of related interdisciplinary researchers

Biomaterials Effect on the Bone Microenvironment focuses on the structure-activity relationship between bone biomaterials and microenvironment regulation, presenting a systematic exposition from all aspects of biomaterials regulated microenvironment in bone regeneration and covering design strategies, applications, and mechanisms of biomaterials that regulate bone microenvironment, along with the methods for manufacturing biomaterials and their clinical translation.

The subject’s potential challenges and future development direction are discussed, and the design and initiative principle of tailored biomaterials with various features, including bioactive components and physicochemical property, are elucidated in depth. Numerous biomaterials, including natural and synthetic, are summarized and compared. Their advantages and features are also evaluated, particularly in bone microenvironmental regulation and bone generation. Moreover, the stimulation mechanism of the microenvironment to bone generation is discussed in detail, including mechanical-support effect, redox effect, pro-angiogenesis effect, inflammatory immune effect, and anti-aging effect.

Biomaterials Effect on the Bone Microenvironment provides further coverage of sample topics such as:

• Role of bone microenvironment and its associated biomaterials in modulation bone diseases, reviewing the biomaterials used to regulate bone microenvironment
• Relationship between biological factors of various materials and physiological functions in bone microenvironment
• Application of the third generation of biomaterials, which would regenerate the bone to regulate bone microenvironment
• Emerging biological material manufacturing technology and mechanisms of novel biomaterial modulating microenvironment for bone regeneration
• Future outlook of bone tissue engineering along with the general process of bone remodeling and regeneration

With comprehensive coverage of one of the most promising and valuable candidates for clinical bone regeneration, Biomaterials Effect on the Bone Microenvironment is an ideal resource for materials scientists, biotechnologists, biochemists, bioengineers, orthopedists, and clinical chemists who want to stay on the cutting edge of this rapidly evolving field.

Jiacan Su is the Department Head of Institute of Translational Medicine, Shanghai University, Shanghai and chief physician of Orthopedics Department, Shanghai Changhai Hospital, Second Military Medical University, Shanghai. Professor Su received his bachelor degree (1999) and M.D. (2004) from Second Military Medical University. He worked as a postdoctoral researcher with Prof. Changsheng Liu at East China University of Science and Technology (2009-2011) and visiting scholar at The Chinese University of Hong Kong (2005-2006), AO centre, Davos (2009), University of Hamburg (2011) and Tampa General Hospital, Tampa (2013), respectively. He was promoted as attending physician (2004) and chief physician & full professor (2015) in the Department of Orthopaedics, Changhai Hospitial Affiliated to SMMU. His research interests include bone degenerative diseases, development and medical application of biomaterials, tissue engineer, etc. Professor Su has authored over 100 scientific publications and has received numerous scientific awards, including the Second prize of China National Technology Progress and Second Prize of Science and Technology Progress of the China Ministry of Education. He is also a member of the International Chinese Musculoskeletal Research Society and a long-time editor of the Annual Review of Bone research.

Yingying Jing, Assistant Professor, Institute of Translational Medicine, Shanghai University, China.

Xiao Chen, Associate Professor, Department of Orthopedics, Shanghai Changhai Hospital, China. His research focuses on biological bone scaffolds, development of anti-osteoporosis drugs and basic research on bone development and bone metabolism.