Genetics of Bipolar Disorder

The high hereditary factor of Bipolar Disorder has been proven by many twin-, adoption- and family-studies already decades ago. Concordance rates between monozygotic twins are even as high as 40-70%. Children of two affected parents have a lifetime-risk of 50-65% to fall ill with Bipolar Disorder, while children with one affected parent show a risk of 25% to get Bipolar Disorder. Therefore psychiatric genetics is highly important to detect the genetic blueprint of Bipolar Disorder to invent prevention strategies, as well as individualized pharmacotherapy and new medication targets. Interestingly top susceptibility genes belong to the ion channel group, growth hormones, clock genes, neurotransmitter systems, Lithium sensitive pathway and other important groups. A detailed and exciting description is given by the authors within this book. Furthermore basic principles of genetics, gene-environment-interactions and genetic overlaps between psychiatric diseases are described to picture the whole painting of Genetics of Bipolar Disorder.

Susanne Bengesser studied Medicine and Molecular Biology (Bachelor degree) at the University of Graz. Currently she works at the department of Psychiatry (Medical University of Graz). Since 2012 she has worked in the outpatient department and research group for Bipolar Disorder as well. Furthermore she is the Co-author of the book Essays im Spannungsbereich von Psychotraumatologie, Ästhetik und Wissenschaftstheorie published by Peter Lang.
Eva Reininghaus studied Medicine at the University of Graz. Furthermore she finished her degree in Medical Sciences. Currently she works at the Psychiatry department of the Medical University of Graz. She has managed the research group for Bipolar Disorder since 2010. Beside she has been a member of the ConLiGen Consortium since 2012.