This volume compiles the complete communications presented at the 10th International Electronic Conference on Sensors and Applications, which was held online from November 15 to 30, together with the contributions of three of the keynote speakers. The conference covered topics such as chemo- and biosensors; physical sensors; sensor networks, the IoT and structural health monitoring; sensor data analytics; and sensors and artificial intelligence. The high levels of participation in this conference have confirmed its leading role as the longest running throughout the history of the Internet, and it continues to serve as a free link between researchers from multiple countries.