Dear Colleagues, this Special Issue presents a comprehensive collection of studies showcasing the latest innovations in dentistry, emphasizing the integration of multidisciplinary approaches and technological advancements. With a focus on improving patient outcomes and advancing oral health care, the contributions explore a range of topics, including the development of new biomaterials, minimally invasive techniques, and novel treatment protocols. These innovations have broad applications in restorative dentistry, prosthodontics, oral surgery, implantology, pediatric dentistry, orthodontics, and the management of temporomandibular disorders. The research presented in this reprint reflects the significant progress made in dental science and its application to clinical practice, offering valuable insights for both researchers and clinicians.