This Special Issue Reprint focuses on "Preventive, Diagnostic and Therapeutic Strategies for Abdominal Surgery Complications". Surgery is indicated to cure or palliate numerous physical ailments, and millions of operations are performed worldwide each year. While the risk of complication overall is low because of the presence of trained and skilled surgeons and the adaption of good surgical techniques, complications can still occur even with the most experienced of surgeons or in the simplest of cases. Surgery can be complicated by adverse effects that can affect daily living by impairing quality of life, increasing the cost of health systems through longer hospitalization times and even increasing mortality and decreasing life expectancy. Complications can be more or less severe, can resolve spontaneously or require medical, interventional or surgical treatment and can be specific to the operation performed or general, but all are significant for the patient and are usually the most difficult part of the patient’s management. Prompt and early diagnosis of complications and adequate and proper treatment are the cornerstones of the successful management of such complications and are all discussed in this reprint.