This is a vivid portrayal of the life and achievements of Georges Köhler, who at age 38 shared a 1984 Nobel Prize with N.K. Jerne and C. Milstein for inventing the technique that generates monoclonal antibodies. That same year, Köhler became a co-director of the Max-Planck-Institute for Immunobiology; his unfortunate death in 1995 cut short an extraordinary career. Written to commemorate the 10th anniversary of his passing, this scientific biography explains Köhler’s pivotal discovery and its momentous influence on research, medicine and the biotech industry in a style understandable to the general public and discussed in the historical context of immunological research.