Monthly variations in the physico-chemical parameters of Mbo River were conducted across three stations, from May to December, 2009. The values ranged from 30.00 to 34.33 C (temperature), 6.70 - 7.32 (pH), 0.5-1.4ppt (salinity), and 6.13 - 8.73mg/l for dissolved oxygen (DO). Monthly variation in the values of DO and temperature were significant (P