There was an effort made in this study to account for the impact of entrepreneurship development on human welfare in Nigeria within the time frame 1990 to 2019. The study sets out to establish, among others, the relationship between the advancement of SMEs and households’ income in Nigeria, the linkage between the advancement development of SMEs and households’ human capital in Nigeria, relationships between the advancement in SMEs and households’ poverty level in Nigeria and the direction of causality between the development of SMEs and household welfare in Nigeria.