The effort to suppress pain caused by surgical procedures through the use of drugs dates back to antiquity, including the oral administration of ethanol and opiates. The study was carried out in a public hospital in Campina Grande-PB, using a qualitative-quantitative approach. Sixty-five patients were analyzed, aged between 41 and 60 years, hysterectomy was the most common procedure and the majority of patients were not hypertensive. Among the anesthetics studied, heavy bupivacaine had the highest incidence in the study, followed by morphine and midazolam. It was also observed that vomiting and dizziness were the most common ADRs. Cephalothin and dipyrone were the most commonly used concomitant drugs. In the post-surgical period, the most commonly used drugs were metoclopramide, followed by dipyrone and cephalothin. The results of this study serve as a basis for future studies on the choice of appropriate anaesthetic techniques for surgical procedures, with the aim of minimizing the occurrence of adverse effects that could prolong hospitalization.