Based on the concept of will in Nietzsche, and the question of Alterity, we point to ontological and ethical questions that are part of contemporary philosophy. In other words, the aim is to analyse the Other in the relationship of Will, which unfolds in an ethical-political sense from a perspective of Alterity as difference. Nietzsche’s articulation of the concepts of love-fate, will to power and beyond man (Übermensch) implies a reading of the alterity necessary to understand human existence. We can then perceive the presence of an Other that is different from the Self, whether in the relationship of power, of will, or even in the overcoming of man, always indicating the need for an Other to be present.