Misoprostol in Cervical Ripening

Premature rupture of the membranes is a frequent obstetrical condition. It affects 8 to 10% of full-term pregnancies, and its optimal management is controversial. Among the agents used to promote cervical ripening are prostaglandins, of which Dinoprostone is the reference molecule.Material and methods This is a prospective, randomized clinical trial conducted at the maternity and neonatology center of Monastir University Hospital over a period of 1 year (January-December 2017).Including 240 parturients presenting with RPM at term and divided into 2 groups: The ＂oral route＂ group: having received 20mcg/ 2h misoprostol solution orally (maximum 6 doses) and the ＂vaginal route＂ group: having received 50mcg/ 6h misoprostol vaginally (maximum 4 doses).Conclusion At the end of this study, the use of low-dose misoprostol by VO for cervical ripening at term, with PDER, is as effective as VV in terms of the rate of deliveries within 24 h, while it is slightly ahead at 12 h (44% versus 33%) without the difference being significant.