Intrauterine insemination (IUI) is a simple method of assisted reproduction often used for unexplained infertility, but its results are sometimes disappointing. A 4-year retrospective study in Tunis examined 196 infertile couples to identify factors predictive of IUI success. With 328 cycles analyzed, the clinical pregnancy rate was 15.2%. Women with polycystic ovary syndrome had the best pregnancy rates (35.1%). Factors influencing success included duration of infertility, basal FSH level, sperm quality and quantity, and endometrial thickness. The results suggest that taking these parameters into account could improve the chances of IUI success.