Urinary tract infection of the newborn is a particular entity which is characterized by its non-specific, often misleading clinical symptoms and its frequent association with malformative uropathy. UTI of the newborn is a condition that requires prompt medical attention due to its potential to cause severe complications. Early recognition of symptoms, accurate diagnosis and appropriate treatment are essential to preserve the renal and general health of the newborn. Prevention through good hygiene and monitoring of newborns at risk also helps reduce the incidence of this infection. In short, a proactive and systematic approach is crucial to guarantee the well-being of the youngest patients.Urinary infection remains a worrying pathology in newborns. Knowing how to prevent it and treat it in time helps reduce its morbidity and mortality.