This study explores oxidative stress in Streptococcus buccale, highlighting its role in pathogenesis and toxin production. Oxidative stress, generated by both internal and external factors, influences the virulence of this bacterium. Metalloenzymes, such as superoxide dismutase and catalase, act as antioxidant defenses, protecting the bacteria from reactive oxygen species. The toxins produced, notably exotoxins, affect host cells, with potentially neurological implications. The accumulation of these toxins in the brain could lead to adverse effects on cognitive health. The interaction between oxidative stress and toxin production highlights the importance of future research to develop targeted treatments. The results also point to significant links with various oral and neurological diseases, reinforcing the importance of an integrated approach to health.