Transfusion-related acute lung injury (TRALI)

Transfusion-related acute pulmonary edema (TRALI) is a transfusion-related incident whose etiology and pathophysiology are still debated, suggesting immunological or non-immunological mechanisms, following leukocyte activation by biological response modifiers (BRMs) supplied by transfused labile blood products (LBP).Using 4 cases of TRALI reported to the haemovigilance unit of the Sfax CRTS, we discuss epidemiology, pathophysiology, positive and differential diagnosis, management and primary and secondary prevention.