Therapeutic patient education (TPE) for patients treated with VKAs has made it possible to improve the safety and efficiency of this treatment by establishing a new doctor-patient relationship. The aim of our study was to assess the impact of an ETP program on the management of patients treated with VKAs.We conducted a comparative prospective interventional study between January and September 2020, including 60 patients. After three months, we observed a more marked improvement in the knowledge score, a better level of therapeutic compliance and a significantly higher TTR in group G1 (p