◎The first book in the world detailing the development history and clinical application of plasma exchange in solving aging problems. ◎Heterochronic Parabiosis is science, not medical. ◎If you are struggling with aging problems, this book will help you understand the root cause of the problems.
Fushih Pan M.D., Ph.D. is not only the only practicing American Boarded Plastic Surgeon but also a well-known pioneer in regenerative medicine in Asia. Dr. Pan began to isolate ADSC (i.e. Adipose-Derived Stem Cells) from the fat of liposuction and re-injected them to rejuvenate facial skin and hair follicles since 2001. In 2003, Dr. Pan established Lotusbio Technology Ltd. to translate his ADSC technologies into the skin and hair care industry. The anti-aging facial serum allowed him to win First Place in Global Launchpad: Beijing in 2012. Since 2015, Dr. Pan became interested in translating the heterochronic parabiosis experimental technologies into clinical practice for the treatment of aging-related diseases and conditions. He set up a transfusion center in Cambodia to study the unique components in the young plasma. Based on this, he was able to create a chemical-defined formulation to simulate the beneficial effects of young plasma. In order to simulate the actual effect of in vivo heterochronic parabiosis, Dr. Pan also developed a mathematical model for heterochronic parabiosis which allows him to calculate and optimize optimal dosage and intervals of intermittent plasma exchange for the individual patient. Dr. Pan received his Ph.D. in Chemistry in 1986 and MD in 1989 both from the University of Chicago. After completed his training in Plastic and Reconstructive Surgery at the University of Chicago Medical Center, he became the Craniofacial Fellow in the Children’s Hospital of Philadelphia and Lecturer in the Department of Surgery at the University of Pennsylvania.
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I am pleased to have the opportunity to recommend this book which brings valuable pieces of information for the benefit of mankind.
I met Dr. Pan on a casual occasion through the introduction of a friend. Dr. Pan is an M.D. and Ph.D. in Chemistry, a reputable plastic surgeon, and a scientist. He has more than 40 years of experience in research and more than 30 years of experience in clinical medicine.
After I took charge of the Wan Hai Lines, I became a firm believer in “Health is Wealth” and have been receiving various anti-aging therapies*. When Dr. Pan explained the science behind heterochronic parabiosis, I immediately became interested and decided to receive the treatment. After only a few sessions, I felt my energy level had improved, the dark shadow of the skin around my toes resolved, and the pigmentation of my face had lightened up. My friends also noticed the changes in my appearance for which I have received many compliments. Since then I have become a great supporter of the plasma exchange program based on the principle of heterochronic parabiosis.
The most unique aspect of the book is that it is organized by a series of questions. Dr. Pan used these questions to guide the readers to explore the vast amount of information in the rapidly growing field of anti-aging medicine. If you read the book carefully, you will understand how scientists are approaching questions by asking one after another one of the questions, followed by carefully designed experiments and analysis of data collected, to find the answer.
After I finished reading this book, I realized that heterochronic parabiosis is more than just an emerging anti-aging medical treatment, it is a science that is based on rigorous scientific principles as compared to medicine which is sometimes more of an art. Just like adding water to a cup of espresso will make it look and tastes lighter, is a science. Heterochronic parabiosis is a technology that makes the blood younger, when the blood becomes younger, the function of the cell will improve, and the aging phenomena are reversed.
If you are interested in the science of aging or anti-aging or want to delay the aging process of your body or improve aging-related diseases or are merely interested in the clinical application of the heterochronic parabiosis technology, I would recommend this book to you without any hesitation.
Dr. Ching-Chih Chen**
Group Chairman Wan Hai Lines Ltd.
** Dr. Ching-Chih Chen is a B.S. in Physics and a Ph.D. in Economics from the Massachusetts Institute of Technology. He was a Professor in Economics at National Taiwan University and a consultant to the Ministry of Finance, Taiwan. He was the President of Wan Hai Lines Ltd. from 1969-1989 and Chairman from 1989-2008, during which he successfully built the company to become one of the largest players in the container shipping industry worldwide.
* Dr. Ching-Chih Chen has received the La Prairie Therapy annually from 1991 till 2000 for 9 consecutive years. He also had been to Morishita Clinic in Nagoya, Japan for placenta tissue therapy 3-4 times a year for 19 years. He began a modified version of intermittent fasting in 2019.
名人推薦：I am pleased to have the opportunity to recommend this book which brings valuable pieces of information for the benefit of mankind.
I met Dr. Pan on a casual occasion through the introduction of a friend. Dr. Pan is an M.D. and Ph.D. in Chemistry, a reputable plastic surgeon, and a scientist. He has more than 40 years of experience in research and more than 30 years of experience in clinical medicine.
After I took charge of the Wan Hai Lines, I became a firm believer in “Health i...
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ort to promote lifestyles in anti-aging and anti- chronic diseases. In contrary to the use of extreme therapies, e.g., respirators, ECMO (i.e., Extracorporeal Membrane Oxygenator), etc., to extend the unhealthy life span.
The goal of the next generation of medicine should be using preventive medicine or regenerative medicine to slow down or even reverse the effect of age (i.e., the aging processes) exerted in health, to maximize the length of healthspan, and preserve independent life until the very end of life.
ort to promote lifestyles in anti-aging and anti- chronic diseases. In contrary to the use of extreme therapies, e.g., respirators, ECMO (i.e., Extracorporeal Membrane Oxygenator), etc., to extend the unhealthy life span.
The goal of the next generation of medicine should be using preventive medicine or regenerative medicine to slow down or even reverse the effect of age (i.e., the aging processes) exerted in health, to maximize the length of healthspan, and preserve independent life until the ...
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作者序
To live and look young forever has been the dream of mankind. Now, for the first time in history, the secret of aging and the method to reverse it has been revealed scientifically red
About 100 hundred years ago, scientists performed an experiment called heterochronic parabiosis to successfully reverse the aging phenomena of old animals in the laboratory.
What is heterochronic parabiosis?
In short, it is the use of materials (e.g., blood, tissue extracts, or stem cells) obtained from young organisms to make the old organism young again.
From 1904 to 1906 at the University of Chicago , Dr. Alexis Carrel was able to connect the vessels of an animal or its organ to another animal and kept it alive for weeks in time. By this technique, he was able to study the effect of aging and the mechanisms of other disease processes. This is the first time and the only experimental method to date where effects of aging reversal could be observed with naked eyes within days.
As a plastic surgeon with a practice focused on facelift procedures, I began to notice the loss of harmony in post-operative patients. As a result, I became very interested in regenerative medical technologies that might rejuvenate the facial appearance in a natural way.
Until the summer of 2012 when the work of Dr. Carrel was brought to my attention incidentally while I was competing in the Global Launch of The Booth Business School of the University of Chicago in Beijing. Based on the immortal theory of cells propose by Carrel, I was able to hypothesize that the blood plasma is like the culture media for the cells inside human body, if we can renew the plasma to a more youthful state, we might be able to reverse the aging process and extend the healthspan of human.
We were able to engineer a formulation to simulate the effect of heterochronic parabiosis in a clinical setting which was later supported by the pioneering work of Conboys’ and Dr. Dobri Kiprov in 2020.
Current protocol for our heterochronic plasma exchange is in three parts. All of the parts could be performed using one small single lumen intravenous catheter easily in an outpatient clinic setting.
During the past few years, we have performed these heterochronic plasma exchange procedures for hundreds of patients with various aging-related problems, such as: Adult-onset diabetes, Alzheimer’s disease, degenerative disc joint diseases, frailty, and for the prevention of local recurrence and metastasis of solid tumors. The expectancy of our patients was largely met as indicated by more than sixty percent of retention rate.
Finally, I sincerely wish the birth of this book will allow those who are interested in anti-aging technologies to gain further understanding of the developmental history, underlying mechanism, and potential clinical applications of anti-aging plasma exchange developed based on the heterochronic parabiosis experiment.
Fu-shih Pan, M.D., Ph.D.
To live and look young forever has been the dream of mankind. Now, for the first time in history, the secret of aging and the method to reverse it has been revealed scientifically red
About 100 hundred years ago, scientists performed an experiment called heterochronic parabiosis to successfully reverse the aging phenomena of old animals in the laboratory.
What is heterochronic parabiosis?
In short, it is the use of materials (e.g., blood, tissue extracts, or stem cells) obtained from young o...
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