Biochemical and Genetic Studies in Women with Recurrent Pregnancy Loss

INTRODUCTION

Recurrent Pregnancy Loss (RPL), otherwise called recurrent miscarriage

(RM), is a frustrating condition affecting around 2-6% of infertile couples and 12-

15% of all pregnancies. Despite intensive workup, no apparent cause can be

identified in at least 50% of couples experiencing RPL. Hence, RPL is very

distressing for both patients and clinicians. ＂The American Society for

Reproductive Medicine (ASRM)＂ defines it ＂as a clinical condition of two or

more failed pregnancies＂ (ASRM 2012).

Nowadays, RPL is widely considered one of the most difficult and

disappointing areas in daily obstetric practice, due to its unclear etiology and the

lack of evidence about the proper clinical management. Moreover, Kolte et al

(2015) explained that ＂RPL can have a profound psychological impact on the

affected couple’s personal life such as grief and depression, hopelessness, guilt,

anxiety, and anger towards the partner, relatives and even to the treating

physician. Many times, it affects the professional life of the partner also＂.