Lean Manufacturing and Six Sigma have joined forces, forming a powerful partnership embraced by many companies. This integration combines the best of both methodologies, harnessing their individual strengths. The result is a comprehensive and effective approach capable of tackling diverse process and product improvement challenges. This book aims to delve into Lean Six Sigma’s application in the manufacturing sector. It covers several critical aspects of Lean Six Sigma, including its principles, tools and techniques, methodologies, critical success factors, framework, strategy, implementation in small and medium enterprises (SMEs), significant benefits, and barriers to implementation, emerging trends in the manufacturing industry. In the ever-evolving business landscape, the book explores emerging trends in Lean Six Sigma. It discusses advancements in technology, the integration of Lean Six Sigma with other improvement methodologies, and the application of Lean Six Sigma beyond manufacturing.