Molecular Biomarkers for Cancer Diagnosis and Therapy

This book presents recent advancements, challenges, and clinical implications of molecular biomarkers in various cancers. This book highlights the clinical applications of biomarkers are extensive for cancer risk assessment, screening and early detection of cancer, accurate diagnosis, patient prognosis, prediction of response to therapy, and cancer surveillance and monitoring response. It also explores the progress of predictive biomarkers as an adjunctive tool to tumor immunotherapy in effectively identifying the efficacy of immune checkpoint inhibitors and discusses their future directions in achieving precision immuno-oncology. Further, the book examines the combination of next-generation sequencing and advanced computational data analysis approaches in the understanding of the genomic underpinnings of cancer development and progression. Towards the end, the chapter discusses the role of some commonly investigated phytochemicals and their epigenetic targets that are of particularinterest in cancer prevention and cancer therapy. It is a must for researchers as well as advanced students and physicians in the field of cancer and clinical oncologists.

Professor Ranbir Chander Sobti is Indian National Science A Senior Scientist Indian Academy of Sciences (INSA) and Emeritus Professor at Punjab University. He is a former Vice-Chancellor of the Panjab University, Chandigarh & Babasaheb Bhimrao Ambedkar University (Central University), Lucknow. He started his career as a cytogeneticist and then moved on to molecular biology, including genomics, to understand the susceptibility and disease process of cancer, COPD, AIDS, metabolic syndrome, and kidney diseases. He has also used stem cells and nanoparticles to understand the process of tissue organ development through a designed de-cellularization protocol. He has published more than 350 research articles in the journals of international repute and has also published more than 50 books. He is a Fellow of the Third World Academy of Sciences, National Academy of Sciences India, Indian National Science Academy, National Academy of Medical Sciences, National Academy of Agricultural Sciences, Canadian Academy of Cardiovascular Diseases and few others. He was the General President of the Indian Science Congress for the 102nd session held at the University of Jammu in 2013. Dr. Sobti is the recipient of many prestigious awards like the INSA Young Scientist Medal, UGC Career Award, Punjab Rattan Award, JC Bose Oration and Sriram Oration Awards and of Life Time Achievement Awards of the Punjab Academy of Sciences, Zoological Society of India, and the Environment Academy of India.He is recipient of most prestigious civil award Padmashri of The Government of India

Professor H Sugimura has served as a Chairman and Vice Director, Hammatsu University School of Medicine for 32 years, and now a Professor Emeritus of Hamamatsu University School of Medicine. He had been a President of Japan Cancer Epidemiology and Molecular Epidemiology. He is an internationally recognized cancer biologist, molecular epidemiologist, and molecular pathologist. He had also worked at University of Tokyo and had been visiting fellow at NCI, NIH Bethesda from 1988-1990. He has published a large number of papers in journals of repute with high impact factor. Currently he serves as a Director of Sasaki Institute, a 140 years old renowned cancer institute, Tokyo

Dr. Aastha Sobti is BDS (Panjab University ), Masters in Clinical Dentistry (University of London ) and Ph.D (Lund University, Sweden). She carried out her research for Ph.D at the Department of Immunotechnology, Lund University, Lund, Sweden, under CanFaster, Marie Sklodowska-Curie COFUND programme. She has a background in dental sciences and did a specialization in master’s in Clinical Dentistry (Oral surgery) from Eastman College, UCL, London. Her core interests are head and neck cancer-based clinical research. In entirety aiding in the field to bring reforms that are required in the present multifarious surgical as well as translational research areas. She has teaching and research experience of about 8 years and published a few papers in international journals of repute. She is a recipient of a large number of prizes and medals for her exceptional work namely the academic certificate of excellence from BAOS, UK and IADR Hatton award (India). Additionally, she has attended and presented papers in international conferences in Hong Kong, Croatia, Brazil, Sweden, UK, Japan, and other countries.