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Ginger is a perennial plant that grows in India, China, Mexico and several other countries. The rhizome is used as both spice and in herbal medicine. Many studies have been done on pharmacological effect of ginger extract and our paper has been focused on cytoprotective effect of ginger on ethanol induced gastric injury in mice. Many drugs have been used in the treatment of peptic ulcer but each of them associated with different side effect so trends today toward use of herbal medicine which was associated with adverse effect. Ginger hydroalcoholic extract contain different consistent with anti-ulcer properties like 6-Gingersulfonic acid and three monoacyldigalactosyl glycerol including ginger glycolipid A. B. C .The mechanism of ginger extract may be due to counteracting the active oxidant radicals, decreasing mucosal cell shedding and thicking the mucus membrane so ginger extract has antiulcer properties when used in accurate dose and accurate duration. Keywords: Cytoprotective effect; Ethanol; Ginger hydroalcoholic extract; Mice; Zingiber Officinal