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Paediatric Dermatology is an expanding subspeciality. This is well illustrated by the growing number of books and articles published on this subject in these recent years. On the other hand, Paediatric Dermatopathology is a relatively recent and less explored niche. There are many skin conditions common in both adults and children. However, some skin disorders are mostly observed in childhood and some entities are restricted to a paediatric age. Paediatric Dermatopathology covers a wide range of disorders including genodermatoses, cutaneous and sub-cutaneous tumours and inflammatory disorders. Nowadays, Paediatricians and Paediatric Dermatologists are no longer reluctant to routinely perform a cutaneous biopsy in a young child, even for a vascular lesion. As a result, Dermatopathologists are more and more called upon to deal with skin biopsies in neonates, infants and children. This Special Issue covers a subset of paediatric dermatological conditions in which a great deal of knowledge has been achieved in recent times, thanks to development of new immunomarkers, application of molecular biology and introduction of new classification system(s). This issue is addressed to Dermatologists and Pathologists interested in Paediatric Dermatopathology.