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This book constitutes the refereed proceedings of the 27th International Conference on Information Integration and Web Intelligence, iiWAS 2025, held in Matsue, Japan, during December 8-10, 2025. The 23 full papers, 12 short papers and 1 keynote paper included in this book were carefully reviewed and selected from 79 submissions. They were organized in topical sections as follows: Keynote; Foundations of AI and Data Intelligence; Knowledge, Reasoning, and Human Interaction; Emerging Technologies and Applied Innovation; Creative and Generative AI.