Afanas’ev Igor B.

　　Exploring major questions regarding signaling mechanisms of reactive oxygen and nitrogen species (ROS/RNS) in enzymatic processes, this volume investigates free radical signaling processes catalyzed by enzymes and examines those producers of superoxide and nitric oxide that use ROS/RNS as signaling species to initiate the process. It considers ROS/RNS sufficiency of signaling production by mitochondrial enzymes, key findings in mitochondrial disorders and subsequent apoptosis, and the development of new treatment potentials for age-related afflictions such as inflammation, cancer, and cardiovascular disease.