A thorough understanding of the mechanisms of acute pain is essential for medical diagnosis and prescription. Differences in acute pain are based on the anatomical type of damaged tissue and the mechanisms of tissue injury. These differences should have an impact on our treatment plan.The multimodal approach is based on the four determining points or phases of the acute pain pathway.How do treatments directly or indirectly affect the different determinants in the resolution of pain perception?The emphasis is on actively interrupting the physiology of these key points.