Przedborski

Parkinson’s disease presents one of the most intricate challenges in neuroscience--a complex disorder with diverse motor and nonmotor symptoms, multifactorial causes, and enigmatic progression patterns. This volume, a thoroughly revised second edition, offers a comprehensive yet accessible synthesis of the clinical and biological foundations of Parkinson’s disease, written explicitly to bridge the gap between clinicians and basic scientists.

Parkinson’s Disease, Second Edition brings together leading experts to provide an integrated view of the disorder’s pathobiology, diagnosis, and emerging therapeutic strategies. It provides both historical context and an understanding of the clinical spectrum, as well as cutting-edge insights into genetics, biomarkers, the gut-brain axis, immune contributions, and neurodegenerative mechanisms.

Highlights include:

• Up-to-date coverage of disease progression, cell-based therapies, and lipid dysregulation
• Deep dives into α-synuclein, LRRK2, and the genetic architecture of familial and sporadic PD
• Examination of neural circuit dysfunction and imaging correlates of symptomatology
• New frontiers in modeling, from rodent to primate and toxin to genetic paradigms
• Explorations of mitochondria, autophagy, and neuroimmune interactions as pathogenic drivers

Intended for neurologists, neuroscientists, molecular biologists, and translational researchers, this book is a guide to entering and contributing to the field of Parkinson’s disease research. For readers in both the clinic and the laboratory, it offers foundational knowledge and an integrative perspective in this rapidly evolving field.